The group of Florian Grebien at the Institute for Medical Biochemistry at the University of Veterinary Medicine Vienna is looking for a motivated individual to work on

Functional studies of fusion-protein-driven leukemia using imaging approaches

Fusion oncoproteins often act as strong cancer drivers. While recent sequencing efforts have identified a high number of novel gene fusions in different cancers, we lack a detailed understanding of the molecular mechanisms that underlie oncogenesis induced by many fusion oncoproteins.

Biomolecular condensation of proteins and RNA is a fundamental principle of organization in all living cells. We and others have recently found that cancer-causing oncoproteins exploit aberrant biomolecular condensation to drive malignant transformation. In this project we aim to develop novel imaging-based tools and combine them with functional genomics and proteomics approaches to obtain a better mechanistic understanding of how fusion oncoproteins form cancer-specific biomolecular condensates and what the functional consequences of these structures are.

The group

The group of Florian Grebien is using a multidisciplinary approach consisting of proteomics, genomics and CRISPR/Cas9-mediated genome engineering in advanced cell line- and mouse models of cancer. By combining wet-lab- and bioinformatics approaches we constantly gain novel insights in the molecular basis of molecular mechanisms of oncogenesis (e.g. see https://doi.org/10.1038/s41467-018-04329-y, https://doi.org/10.1182/blood.2019003267, https://doi.org/10.1038/s41594-020-00550-w, and https://doi.org/10.1182/blood.2022016592).

Our laboratory is embedded in the infrastructure of the Department for Biomedical Sciences at the University of Veterinary Medicine Vienna. The wider network of the group is constituted by several close national and international collaborations.

The candidate

We are looking for a motivated researcher who holds a diploma- or MSc degree in Biology, Molecular Biology, Biotechnology, Biochemistry, Human or Veterinary Medicine or a related topic and has a track record in biochemistry, cellular and molecular biology or cancer research. Previous experience in cell culture, molecular biology and/or imaging approaches are a plus. The successful candidate is an individual thinker who is ambitious and self-driven. Excellent organizational skills and written and oral communication skills in English are required. If you are a curious, flexible and social person who is interested to work in an interdisciplinary team you should look into this opportunity.

Please submit a letter of motivation, a detailed Curriculum Vitae including a publication list as well as reference letters and contact details of three suggested referees to Florian Grebien (florian.grebien@vetmeduni.ac.at) The earliest possible starting date is January 1, 2023.

Applications are accepted until the position is filled.