Master student position

The group of Florian Grebien at the Institute for Medical Biochemistry at the University of Veterinary Medicine Vienna is looking for a motivated individual to work on

Epigenetic characterization of fusion oncoprotein-driven leukemia

The project aims at understanding molecular mechanisms underlying acute myeloid leukemia driven by oncogenic fusion proteins. The student will establish and apply state-of-the-art approaches (such as ChIP-seq and CUT&RUN) to investigate the epigenetic landscape in relevant cellular models enabling targeted protein degradation of oncogenic drivers. In addition to providing insights into the fields of cancer biology and leukemogenesis, this thesis offers access to diverse methodologies in cell biology, biochemistry and molecular biology, including CRISPR/Cas9-medited genome engineering, mouse models of leukemia, flow cytometry, western blot, assays of cell proliferation and survival, RNA-seq, ChIP-seq and others. The successful applicant will join a dynamic and versatile laboratory experienced in molecular and cellular biology.

The group

The group of Florian Grebien is using a multidisciplinary approach consisting of proteomics, genomics and CRISPR/Cas9-mediated genome engineering in advanced cell line- and mouse models of cancer. By combining wet-lab- and bioinformatics approaches we constantly gain novel insights in the molecular basis of molecular mechanisms of leukemogenesis (e.g. see https://doi.org/10.1038/s41467-018-04329-y, https://doi.org/10.1182/blood.2019003267 , https://doi.org/10.1038/s41594-020-00550-w and https://doi.org/10.1182/blood.2022016592)

The candidate:

We are looking for a motivated student who holds a bachelor degree in biomedical sciences (biology, medicine, genetics, biochemistry, biotechnology) or in a related field and has a strong interest in cancer biology. Previous experience in cell culture as well as basic molecular biology skills are an asset. As the working language is English, advanced written and oral communication skills are required, as well as high accuracy, reliability and very good interpersonal skills.

Application details:

If the profile fits you and you would like to be part of a dynamic and ambitious research group, please send a letter of motivation, a detailed curriculum vitae, reference letters and contact details of two suggested referees to Selina.Troester@vetmeduni.ac.at.

The starting date will be between November 2022 and January 2023, and applications will be considered until the position is filled. Financial support will be provided according to the guidelines of the collective agreement.