The group of Florian Grebien at the Institute for Medical Biochemistry at the University of Veterinary Medicine Vienna is looking for a motivated individual to work on

 Oncogenic mechanisms in fusion-driven cancers

Fusion oncoproteins often act as strong cancer drivers. While recent sequencing efforts have identified a high number of novel gene fusions in different cancers, we lack a detailed understanding of the molecular mechanisms that underlie oncogenesis induced by many fusion oncoproteins.

In this project we will study oncogenic mechanisms of fusion proteins that drive aggressive cancers in bone and soft tissue of children, adolescents and young adults through a combination of cell line engineering, functional genomics, proteomics and imaging. The project will involve experimental work as well as bioinformatic analysis and integration of datasets that are publicly available or were generated in-house.

The group

The group of Florian Grebien is using a multidisciplinary approach consisting of proteomics, genomics and CRISPR/Cas9-mediated genome engineering in advanced cell line- and mouse models of cancer. By combining wet-lab- and bioinformatics approaches we constantly gain novel insights in the molecular basis of molecular mechanisms of oncogenesis (e.g. see https://doi.org/10.1038/s41467-018-04329-y, https://doi.org/10.1182/blood.2019003267 and https://doi.org/10.1038/s41594-020-00550-w)

Our laboratory is embedded in the existing infrastructure of the Department for Biomedical Sciences at the University of Veterinary Medicine Vienna. The wider network of the group is constituted by several close national and international collaborations.

The candidate:

We are looking for a motivated researcher who holds a PhD (MD, DVM or equivalent) degree and has an excellent track record in biochemistry, cellular and molecular biology and cancer research, as documented by relevant publications in the field. Previous experience in the fields of epigenetics, transcriptional control or the CRISPR/Cas9 technology is a plus. The successful candidate is an individual thinker who is ambitious and self-driven. Excellent organizational skills and written and oral communication skills in English are required. If you are a curious, flexible and social person who is interested to work in an interdisciplinary team you should look into this opportunity.

Please submit a letter of motivation, a detailed Curriculum Vitae including a publication list as well as reference letters and contact details of three suggested referees to Florian Grebien (florian.grebien@vetmeduni.ac.at) The earliest possible starting date is January 1, 2023.

Applications are accepted until the position is filled.