The group of Florian Grebien at the Institute for Medical Biochemistry at the University of Veterinary Medicine Vienna is looking for a motivated and experienced individual to work on Biomolecular condensation in fusion protein-driven cancer.
Biomolecular condensation of proteins and RNA is a fundamental principle of organization in all living cells. We and others have recently found that that cancer-causing oncoproteins exploit aberrant biomolecular condensation to drive malignant transformation. In this project we aim to use a combination of modern imaging methods and CRISPR/Cas9-medaited genome engineering to obtain a better mechanistic understanding of how RNA and proteins form cancer-specific oncogenic biomolecular condensates.
The group of Florian Grebien is using a multidisciplinary approach consisting of proteomics, genomics as well as imaging and CRISPR/Cas9-mediated genome engineering in advanced cell line- and mouse models of cancer. By combining wet-lab- and bioinformatics approaches we constantly gain novel insights in the molecular basis of fusion protein-driven development (e.g. see Terlecki-Zaniewicz et al, Nat Struct Mol Biol, 2021, https://www.nature.com/articles/s41594-020-00550-w)
Our laboratory is embedded in the existing infrastructure of the Department for Biomedical Sciences at the University of Veterinary Medicine Vienna. The wider network of the group is constituted by several close national and international collaborations.
We are looking for a motivated researcher who holds a PhD (DVM, MD or equivalent) degree and has an excellent track record in biochemistry, cellular and molecular biology and cancer research, as documented by relevant publications in the field. Previous experience with modern imaging methods is a plus. The successful candidate is an individual thinker who is ambitious and self-driven. Excellent organizational skills and written and oral communication skills in English are required.
If you are a curious, flexible and social person who is interested to work in an interdisciplinary team you should look into this opportunity.
Please submit a letter of motivation, a detailed Curriculum Vitae including a publication list as well as reference letters and contact details of three suggested referees to Florian Grebien (firstname.lastname@example.org) The anticipated Starting date is January 1st, 2022.
Applications are accepted until the position is filled.