2019
All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia
Nguyen CH, Bauer K, Hackl H, Schlerka A, Koller E, Hladik A, Stoiber D, Zuber J, Staber PB, Hoelbl-Kovacic A, Purton LE, Grebien F, Wieser R.
Cell Death and Disease; December 2019, 10(12):944, available at https://pubmed.ncbi.nlm.nih.gov/31822659/
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
Menzl I, Zhang T, Berger-Becvar A, Grausenburger R, Heller G, Prchal-Murphy M, Edlinger L, Knab VM, Uras IZ, Grundschober E, Bauer K, Roth M, Skucha A, Liu Y, Hatcher JM, Liang Y, Kwiatkowski NP, Fux D, Hoelbl-Kovacic A, Kubicek S, Melo JV, Valent P, Weichhart T, Grebien F, Zuber J, Gray NS, Sexl V.
Nature Communications; October 2019, 10(1):4741. available at https://pubmed.ncbi.nlm.nih.gov/31628323/
CEBPA-Mutated Leukemia Is Sensitive to Genetic and Pharmacological Targeting of the MLL1 Complex
Schmidt L, Heyes E, Scheiblecker L, Eder T, Volpe G, Frampton J, Nerlov C, Valent P, Grembecka J, Grebien F.
Leukemia; July 2019, 33(7): 1608–19, available at http://www.ncbi.nlm.nih.gov/pubmed/30679799
STAT3β Is a Tumor Suppressor in Acute Myeloid Leukemia
Aigner P, Mizutani T, Horvath J, Eder T, Heber S, Lind K, Just V, Moll HP, Yeroslaviz A, Fischer MJM, Kenner L, Győrffy B, Sill H, Grebien F, Moriggl R, Casanova E, Stoiber D.
Blood Advances; July 2019, 3(13): 1989–2002, available at https://www.ncbi.nlm.nih.gov/pubmed/31270081
High Activation of STAT5A Drives Peripheral T-Cell Lymphoma and Leukemia
Maurer B, Nivarthi H, Wingelhofer B, Pham HTT, Schlederer M, Suske T, Grausenburger R, Schiefer A-I, Prchal-Murphy M, Chen D, Winkler S, Merkel O, Kornauth C, Hofbauer M, Hochgatterer B, Hoermann G, Hoelbl-Kovacic A, Prochazkova J, Lobello C, Cumaraswamy AA, Latzka J, Kitzwögerer M, Chott A, Janikova A, Pospíšilova Š, Loizou JI, Kubicek S, Valent P, Kolbe T, Grebien F, Kenner L, Gunning PT, Kralovics R, Herling M, Müller M, Rülicke T, Sexl V, Moriggl R
Haematologica; May 2019, available at http://www.ncbi.nlm.nih.gov/pubmed/31123029
The Phosphatase UBASH3B/Sts-1 Is a Negative Regulator of Bcr-Abl Kinase Activity and Leukemogenesis
Mian AA, Baumann I, Liebermann M, Grebien F, Superti-Furga G, Ruthardt M, Ottmann OG, Hantschel O
Leukemia; April 2019, available at http://www.ncbi.nlm.nih.gov/pubmed/30962580
Dependence on Myb Expression Is Attenuated in Myeloid Leukaemia with N-Terminal CEBPA Mutations
Volpe G, Cauchy P, Walton DS, Ward C, Blakemore D, Bayley R, Clarke ML, Schmidt L, Nerlov C, Garcia P, Dumon S, Grebien F, Frampton J
Life Science Alliance; April 2019, 2(2): e201800207, available at https://www.ncbi.nlm.nih.gov/pubmed/30877232
Dependency on the TYK2/STAT1/MCL1 Axis in Anaplastic Large Cell Lymphoma
Prutsch N, Gurnhofer E, Suske T, Liang HC, Schlederer M, Roos S, Wu LC, Simonitsch-Klupp I, Alvarez-Hernandez A, Kornauth C, Leone DA, Svinka J, Eferl R, Limberger T, Aufinger A, Shirsath N, Wolf P, Hielscher T, Aberger F, Schmoellerl J, Stoiber D, Strobl B, Jäger U, Staber PB, Grebien F, Moriggl R, Müller M, Inghirami GG, Sanda T, Look AT, Turner SD, Kenner L, Merkel O
Leukemia; March 2019, 33(3): 696–709, available at http://www.ncbi.nlm.nih.gov/pubmed/30131584
Altered Splicing and Cytoplasmic Levels of TRNA Synthetases in SF3B1-Mutant Myelodysplastic Syndromes as a Therapeutic Vulnerability
Liberante FG, Lappin K, Barros EM, Vohhodina J, Grebien F, Savage KI, Mills KI
Scientific reports; February 2019, 9(1): 2678, available at http://www.ncbi.nlm.nih.gov/pubmed/30804405
Roles of Setd2 in Leukemia—Transcription, Dna-Damage, and Beyond
Skucha A, Ebner J, Grebien F
International Journal of Molecular Sciences; February 2019, 20(5), available at http://www.ncbi.nlm.nih.gov/pubmed/30818762
2018
SETD2 in MLL-Rearranged Leukemia – a Complex Case
Skucha A, Ebner J, Grebien F
Molecular & cellular oncology; August 2018, 5(4): e1503492, available at http://www.ncbi.nlm.nih.gov/pubmed/30250934
Oxytocin-like Signaling in Ants Influences Metabolic Gene Expression and Locomotor Activity
Liutkevičiutė Z, Gil-Mansilla E, Eder T, Casillas-Pérez B, Di Giglio MG, Muratspahić E, Grebien F, Rattei T, Muttenthaler M, Cremer S, Gruber CW
FASEB Journal; June 2018, 32(12): 6808–21, available at http://www.ncbi.nlm.nih.gov/pubmed/29939785
MLL-Fusion-Driven Leukemia Requires SETD2 to Safeguard Genomic Integrity
Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César-Razquin A, Stukalov A, Vittori S, Muhar M, Lu B, Aichinger M, Jude J, Müller AC, Győrffy B, Vakoc CR, Valent P, Bennett KL, Zuber J, Superti-Furga G, Grebien F
Nature communications; May 2018, 9(1): 1983, available at http://www.ncbi.nlm.nih.gov/pubmed/29777171
Pharmacologic Inhibition of STAT5 in Acute Myeloid Leukemia
Wingelhofer B, Maurer B, Heyes EC, Cumaraswamy AA, Berger-Becvar A, de Araujo ED, Orlova A, Freund P, Ruge F, Park J, Tin G, Ahmar S, Lardeau C-H, Sadovnik I, Bajusz D, Keserű GM, Grebien F, Kubicek S, Valent P, Gunning PT, Moriggl R
Leukemia; May 2018, 32(5): 1135–46, available at http://www.ncbi.nlm.nih.gov/pubmed/29472718
STAT5BN642H Is a Driver Mutation for T Cell Neoplasia
Pham HTT, Maurer B, Prchal-Murphy M, Grausenburger R, Grundschober E, Javaheri T, Nivarthi H, Boersma A, Kolbe T, Elabd M, Halbritter F, Pencik J, Kazemi Z, Grebien F, Hengstschläger M, Kenner L, Kubicek S, Farlik M, Bock C, Valent P, Müller M, Rülicke T, Sexl V, Moriggl R
The Journal of clinical investigation; January 2018, 128(1): 387–401, available at http://www.ncbi.nlm.nih.gov/pubmed/29200404
2017
Nilotinib-Induced Vasculopathy: Identification of Vascular Endothelial Cells as a Primary Target Site
Hadzijusufovic E, Albrecht-Schgoer K, Huber K, Hoermann G, Grebien F, Eisenwort G, Schgoer W, Herndlhofer S, Kaun C, Theurl M, Sperr WR, Rix U, Sadovnik I, Jilma B, Schernthaner GH, Wojta J, Wolf D, Superti-Furga G, Kirchmair R, Valent P
Leukemia; November 2017, 31(11): 2388–97, available at http://www.ncbi.nlm.nih.gov/pubmed/28757617
Analysis of the Interplay between All-Trans Retinoic Acid and Histone Deacetylase Inhibitors in Leukemic Cells
Noack K, Mahendrarajah N, Hennig D, Schmidt L, Grebien F, Hildebrand D, Christmann M, Kaina B, Sellmer A, Mahboobi S, Kubatzky K, Heinzel T, Krämer OH
Archives of toxicology; May 2017, 91(5): 2191–2208, available at http://www.ncbi.nlm.nih.gov/pubmed/27807597
2016
NVT: A Fast and Simple Tool for the Assessment of RNA-Seq Normalization Strategies
Eder T, Grebien F, Rattei T
Bioinformatics (Oxford, England); December 2016, 32(23): 3682–84, available at http://www.ncbi.nlm.nih.gov/pubmed/27515738
JAK-STAT Signaling in Cancer: From Cytokines to Non-Coding Genome
Pencik J, Pham HTT, Schmoellerl J, Javaheri T, Schlederer M, Culig Z, Merkel O, Moriggl R, Grebien F, Kenner L
Cytokine; November 2016, 87: 26–36, available at http://www.ncbi.nlm.nih.gov/pubmed/27349799
Increased Survival and Cell Cycle Progression Pathways Are Required for EWS/FLI1-Induced Malignant Transformation
Javaheri T, Kazemi Z, Pencik J, Pham HT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DN, Wiedner M, Tomazou EM, Logan M, Hartmann C, Tuckermann JP, Kenner L, Mikula M, Dolznig H, Üren A, Richter GH, Grebien F, Kovar H, Moriggl R
Cell death & disease; October 2016, 7(10): e2419, available at http://www.ncbi.nlm.nih.gov/pubmed/27735950
2015
Pharmacological Targeting of the Wdr5-MLL Interaction in C/EBPα N-Terminal Leukemia
Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KVM, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G
Nature chemical biology; August 2015, 11(8): 571–78, available at http://www.ncbi.nlm.nih.gov/pubmed/26167872
STAT3 Regulated ARF Expression Suppresses Prostate Cancer Metastasis
Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L
Nature communications; July 2015, 6: 7736, available at http://www.ncbi.nlm.nih.gov/pubmed/26198641
2014 and earlier
Acceleration of Bcr-Abl+ Leukemia Induced by Deletion of JAK2
Grundschober E, Hoelbl-Kovacic A, Bhagwat N, Kovacic B, Scheicher R, Eckelhart E, Kollmann K, Keller M, Grebien F, Wagner KU, Levine RL, Sexl V
Leukemia; September 2014, 28(9): 1918–22, available at http://www.ncbi.nlm.nih.gov/pubmed/24791858
Perturbation of the Mutated EGFR Interactome Identifies Vulnerabilities and Resistance Mechanisms
Li J, Bennett K, Stukalov A, Fang B, Zhang G, Yoshida T, Okamoto I, Kim JY, Song L, Bai Y, Qian X, Rawal B, Schell M, Grebien F, Winter G, Rix U, Eschrich S, Colinge J, Koomen J, Superti-Furga G, Haura EB
Molecular Systems Biology; November 2013, 9: 705, available at http://www.ncbi.nlm.nih.gov/pubmed/24189400
Affinity Purification Strategies for Proteomic Analysis of Transcription Factor Complexes
Giambruno R, Grebien F, Stukalov A, Knoll C, Planyavsky M, Rudashevskaya EL, Colinge J, Superti-Furga G, Bennett KL
Journal of proteome research; September 2013, 12(9): 4018–27, available at http://www.ncbi.nlm.nih.gov/pubmed/23937658
Systems-Pharmacology Dissection of a Drug Synergy in Imatinib-Resistant CML
Winter GE, Rix U, Carlson SM, Gleixner K V, Grebien F, Gridling M, Müller AC, Breitwieser FP, Bilban M, Colinge J, Valent P, Bennett KL, White FM, Superti-Furga G
Nature chemical biology; November 2012, 8(11): 905–12, available at http://www.ncbi.nlm.nih.gov/pubmed/23023260
The Growing Arsenal of ATP-Competitive and Allosteric Inhibitors of BCR-ABL
Hantschel O, Grebien F, Superti-Furga G
Cancer research; October 2012, 72(19): 4890–95, available at http://www.ncbi.nlm.nih.gov/pubmed/23002203
Optimisation of Downscaled Tandem Affinity Purifications to Identify Core Protein Complexes
Haura EB, Sacco R, Li J, Müller AC, Grebien F, Superti-Furga G, Bennett KL
Journal of integrated OMICS; May 2012, 2(1): 55–68, available at http://www.ncbi.nlm.nih.gov/pubmed/24077984
BCR-ABL Uncouples Canonical JAK2-STAT5 Signaling in Chronic Myeloid Leukemia
Hantschel O, Warsch W, Eckelhart E, Kaupe I, Grebien F, Wagner K-U, Superti-Furga G, Sexl V
Nature chemical biology; January 2012, 8(3): 285–93, available at http://www.ncbi.nlm.nih.gov/pubmed/22286129
Targeting Allosteric Regulatory Modules in Oncoproteins: “Drugging the Undruggable”
Hantschel O, Grebien F, Superti-Furga G
Oncotarget; November 2011, 2(11): 828–29, available at http://www.ncbi.nlm.nih.gov/pubmed/22084171
Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis
Grebien F, Hantschel O, Wojcik J, Kaupe I, Kovacic B, Wyrzucki AM, Gish GD, Cerny-Reiterer S, Koide A, Beug H, Pawson T, Valent P, Koide S, Superti-Furga G
Cell; October 2011, 147(2): 306–19, available at http://www.ncbi.nlm.nih.gov/pubmed/22000011
Using ITRAQ Combined with Tandem Affinity Purification to Enhance Low-Abundance Proteins Associated with Somatically Mutated EGFR Core Complexes in Lung Cancer
Haura EB, Müller A, Breitwieser FP, Li J, Grebien F, Colinge J, Bennett KL
Journal of proteome research; January 2011, 10(1): 182–90, available at http://www.ncbi.nlm.nih.gov/pubmed/20945942
CD14 Is a Coreceptor of Toll-like Receptors 7 and 9
Baumann CL, Aspalter IM, Sharif O, Pichlmair A, Blüml S, Grebien F, Bruckner M, Pasierbek P, Aumayr K, Planyavsky M, Bennett KL, Colinge J, Knapp S, Superti-Furga G
The Journal of experimental medicine; November 2010, 207(12): 2689–2701, available at http://www.ncbi.nlm.nih.gov/pubmed/21078886
A Potent and Highly Specific FN3 Monobody Inhibitor of the Abl SH2 Domain
Wojcik J, Hantschel O, Grebien F, Kaupe I, Bennett KL, Barkinge J, Jones RB, Koide A, Superti-Furga G, Koide S
Nature structural & molecular biology; April 2010, 17(4): 519–27, available at http://www.ncbi.nlm.nih.gov/pubmed/20357770
Stat5 Is Indispensable for the Maintenance of Bcr/Abl-Positive Leukaemia
Hoelbl A, Schuster C, Kovacic B, Zhu B, Wickre M, Hoelzl MA, Fajmann S, Grebien F, Warsch W, Stengl G, Hennighausen L, Poli V, Beug H, Moriggl R, Sexl V
EMBO molecular medicine; March 2010, 2(3): 98–110, available at http://www.ncbi.nlm.nih.gov/pubmed/20201032
Stat5 Regulates Cellular Iron Uptake of Erythroid Cells via IRP-2 and TfR-1
Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, Beug H, Moriggl R, Müllner EW
Blood; November 2008, 112(9): 3878–88, available at http://www.ncbi.nlm.nih.gov/pubmed/18694996
Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S
Cell; September 2008, 134(5): 793–803, available at http://www.ncbi.nlm.nih.gov/pubmed/18775312
Stat5 Activation Enables Erythropoiesis in the Absence of EpoR and Jak2
Grebien F, Kerenyi MA, Kovacic B, Kolbe T, Becker V, Dolznig H, Pfeffer K, Klingmüller U, Müller M, Beug H, Müllner EW, Moriggl R
Blood; May 2008, 111(9): 4511–22, available at http://www.ncbi.nlm.nih.gov/pubmed/18239084
The Different Functions of Stat5 and Chromatin Alteration through Stat5 Proteins
Kornfeld JW, Grebien F, Kerenyi MA, Friedbichler K, Kovacic B, Zankl B, Hoelbl A, Nivarti H, Beug H, Sexl V, Muller M, Kenner L, Mullner EW, Gouilleux F, Moriggl R
Frontiers in Bioscience; May 2008, (13): 6237–54, available at http://www.ncbi.nlm.nih.gov/pubmed/18508657
Erythroid Progenitor Renewal versus Differentiation: Genetic Evidence for Cell Autonomous, Essential Functions of EpoR, Stat5 and the GR
Dolznig H, Grebien F, Deiner EM, Stangl K, Kolbus A, Habermann B, Kerenyi MA, Kieslinger M, Moriggl R, Beug H, Müllner EW
Oncogene; May 2006, 25(20): 2890–2900, available at http://www.ncbi.nlm.nih.gov/pubmed/16407844
Cell Size Control: New Evidence for a General Mechanism
Grebien F, Dolznig H, Beug H, Mullner EW
Cell cycle (Georgetown, Tex.); March 2005, 4(3): 418–21, available at http://www.ncbi.nlm.nih.gov/pubmed/15703475
Evidence for a Size-Sensing Mechanism in Animal Cells
Dolznig Helmut, Grebien F, Sauer T, Beug H, Müllner EW
Nature cell biology; September 2004, 6(9): 899–905, available at http://www.ncbi.nlm.nih.gov/pubmed/15322555
The Grebien Group 