Florian Grebien did his PhD jointly supervised by Ernst Müllner of the Medical University Vienna and Hartmut Beug of the Research Institute for Molecular Pathology (IMP) in Vienna. For his post-doctoral research he joined the team of Giulio Superti-Furga at the Research Center for Molecular Medicine (CeMM), Vienna. From 2014 to 2018, he was a Principal Investigator and group leader at the Ludwig Boltzmann Institute for Cancer Research (LBI-CR) in Vienna. In January 2018, he was appointed Professor and head of the institute for Medical Biochemistry at the University of Veterinary Medicine Vienna. Since 2023, Florian is also a Principal Investigator at the St. Anna Children’s Cancer Research Institute (CCRI) and an Adjunct Principal Investigator at CeMM.
Florian Grebien’s
research focuses on acute myeloid leukemia (AML), a cancer of white blood cells
that is characterized by the rapid growth of abnormal myeloid cells that
accumulate in the bone marrow and interfere with the production of normal blood
cells. The Grebien laboratory aims to contribute to a better understanding of
the molecular mechanisms of leukemia development. We study cellular and
molecular effects of leukemia-associated oncoproteins through the development
and use of novel tools, including cell culture and mouse models, Next
Generation Sequencing, Mass Spectrometry and primary patient samples.
Manuela Thullner
Secretary
Thomas Eder
Bioinformatician
“As bioinformatician I have a special interest in cutting edge NGS technologies, the resulting data and its applications as well as tool development. My research focuses on normalization methods and techniques used for differential gene expression and differential ChIP-seq.”
Christina Horstmann
PhD student
“My aim is to analyze the role of zinc-finger containing proteins in AML and to target them making use of chemical biology.”
Elisa Manieri
Junior Principal Investigator
“I am investigating the complex interactions between fibroblasts and colorectal cancer cells, focusing on the role of Pdgfra+ fibroblasts in tumor development and metastasis. By using cutting-edge technologies, such as single-cell RNA sequencing, organoids, mouse models and high-resolution imaging, my aim is to identify and validate fibroblast- and epithelial-secreted factors that influence cellular crosstalk.”
Martin Piontek
PhD student
“My research focuses on molecular factors that mediate the response to recently estabilished targeted therapies in acute myeloid leukemia.”
Alice Soardo
PhD student
“My project aims to characterize the molecular crosstalk between intestinal epithelial cells and fibroblasts during tumorigenesis, with the goal of identifying novel tumor vulnerabilities and potential therapeutic targets within the stromal compartment.”
Patricia Testori
PhD student
“My aim is to identify molecular determinants of sensitivity/resistance to anticancer drugs and to shed light on reliable biomarkers to predict treatment response of canine DLBCL. “
Anna Vidal
PhD student
“My work aims to understand the complexity of melanoma brain metastasis formation. I use CRISPRa/i systems on patient derived melanoma cell lines to study the interaction with astrocytes and the role of CD271.”
Some of the photos were kindly provided by Michael Bernkopf, Vetmeduni Vienna.
The Grebien Lab 