Our Lab

Florian Grebien
Principal investigator

Florian Grebien did his PhD jointly supervised by Ernst Müllner of the Medical University Vienna and Hartmut Beug of the Research Institute for Molecular Pathology (IMP) in Vienna. For his post-doctoral research he joined the team of Giulio Superti-Furga at the Research Center for Molecular Medicine (CeMM), Vienna. From 2014 to 2018, he was a Principal Investigator and group leader at the Ludwig Boltzmann Institute for Cancer Research (LBI-CR) in Vienna. In January 2018, he was appointed Professor and head of the institute for Medical Biochemistry at the University of Veterinary Medicine Vienna.

Florian Grebien’s research focuses on acute myeloid leukemia (AML), a cancer of white blood cells that is characterized by the rapid growth of abnormal myeloid cells that accumulate in the bone marrow and interfere with the production of normal blood cells. The Grebien laboratory aims to contribute to a better understanding of the molecular mechanisms of leukemia development. We study cellular and molecular effects of leukemia-associated oncoproteins through the development and use of novel tools, including cell culture and mouse models, Next Generation Sequencing, Mass Spectrometry and primary patient samples.

Manuela Thullner
Secretary

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Melanie Allram
PhD student

“I am investigating NUP98-fusion proteins and their interaction partners in the context of biomolecular condensates as drivers for leukemogenic gene expression.”

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Jessica Ebner
PhD student

“I aim to investigate new therapeutic targets in acute myeloid leukemia to improve targeted therapy. I am currently working on drug synergies and synthetic lethal interactions in acute myeloid leukemia.”

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Thomas Eder
PostDoc

“As bioinformatician I have a special interest in cutting edge NGS technologies, the resulting data and its applications as well as tool development. My research focuses on normalization methods and techniques used for differential gene expression and differential ChIP-seq.”

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Elizabeth Heyes
PostDoc

“I am studying cooperative effects of frequently co-occurring mutations in AML. I am using CRISPR/Cas9 to generate novel in vitro and in vivo models, which I analyze via state-of-the-art NGS technologies”

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Ecem Kirkiz
PhD student

“I study the regulators of NUP98-fusion oncoprotein homeostasis with the aim of reversing leukaemogenic effects of fusion proteins by targeting such regulators.”

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Gabriele Manhart
Technician (and artist)

“Eager to acquire experience in state of the art techniques and gain a profound background in cancer research, specifically acute myeloid leukaemia, I am participating in various projects and help wherever needed.”

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Pablo Fernandez Pernas
PostDoc

“I am investigating the role of biomolecular condensation in oncogenic transformation driven by NUP98-fusion proteins using state-of-the-art cellular models, advanced imaging tools, and novel MS-based proteomics.”

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Martin Piontek
PhD student

“My research focuses on molecular factors that mediate the response to recently estabilished targeted therapies in acute myeloid leukemia.”

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Ludovica Proietti
PhD student

“I aim to investigate the role of RNA metabolism in the context of leukemogenesis in different AML cell lines.”

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Patricia Testori
MSc student

“My goal is to elucidate the role of GATA2 in AML by generating relevant models. “

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Selina Tröster
PhD student

“My aim is to establish novel models for the study of NUP98-fusion proteins to investigate cellular processes important for leukemia caused by these fusion proteins.”

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Anna Vidal
PhD student

“My work aims to understand the complexity of melanoma brain metastasis formation. I use CRISPRa/i systems on patient derived melanoma cell lines to study the interaction with astrocytes and the role of CD271.”

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