PhD position in Acute Myeloid Leukemia Research

We are looking for a motivated individual to join the laboratory of Florian Grebien as a PhD student to work on

Biomolecular condensation in fusion-protein-dependent AML

Acute myeloid leukemia (AML) is often caused by fusion proteins, which originate from chromosomal rearrangements. A better understanding of how fusion-proteins hijack cellular machineries to induce AML will lead to the development of more effective treatment options of affected AML patients.

The project:

To study the molecular basis of fusion-protein induced AML development, the Grebien group has built an array of modern tools, combining engineered cell lines and in vivo models with genome-scale CRISPR/Cas9 screening, proteomics, gene expression analysis as well as cell biological, biochemical and pharmacological approaches. In this project we aim to investigate the concept of biomolecular condensation in the context of fusion-protein-induced oncogenesis. The student will combine CRISPR/Cas9-mediated genome engineering with modern imaging technologies and newly developed proteomics approaches to identify molecular mechanisms in fusion-protein induced leukemogenesis.

The group:

The Grebien group is located in generously refurbished laboratory and office space at the Institute of Medical Biochemistry at the University of Veterinary Medicine Vienna. It is embedded in the research infrastructure of the Department of Biomedical Sciences. The wider network of the group is constituted by several close national and international collaborations.

The candidate:

We are seeking a motivated individual with profound training in biology, molecular biology or biochemistry (M.D., D.V.M. or M.Sc. degree). Evidence of successful previous laboratory work is essential. Experience with CRISPR/Cas9-mediated genome engineering, imaging or proteomics will be an asset. Efficiency in handling large datasets is required, and experience with programming languages will be a plus. The successful candidate is an individual thinker with excellent organizational skills and good writing and oral communication skills in English.

If you are a curious, flexible and social person who is interested to work in an interdisciplinary project, then apply via email to bewerbungen@vetmeduni.ac.at using the reference 2020/1112.

In case you want to know more about the position contact florian.grebien@vetmeduni.ac.at .

Please submit a letter of motivation, a detailed Curriculum Vitae as well as reference letters and contact details of at least two suggested referees.

If you are interested in working in our lab, feel free to send us your CV and letter of motivation (Contact). We are always happy to hear from motivated and eager scientists.